Vázquez-Cuesta Silvia, Olmedo María, Reigadas Elena, Alcalá Luis, Marín Mercedes, Muñoz Patricia, Bouza Emilio
Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Front Med (Lausanne). 2022 Aug 22;9:953724. doi: 10.3389/fmed.2022.953724. eCollection 2022.
Information on infection (CDI) in patients with COVID-19 is scarce and points to an overall decrease of episodes during the pandemic. This situation results paradoxical, as COVID-19 patients had long periods of hospital stay and high use of antibiotics. We conducted a retrospective study from January 1st 2019 to December 31st 2020 comparing the incidence of hospital-acquired episodes of CDI (HA-CDI) among patients with and without COVID-19 admitted to our institution. During the study period, there were 47,048 patient admissions in 2019, 35,662 admissions of patients without COVID-19 in 2020 and 6,763 of COVID-19 patients. There were 68 episodes of HA-CDI in COVID-19 patients (14.75/10,000 days), 159 in 2020-non-COVID-19 patients (5.54/10,000 days) and 238 in 2019 (6.80/10,000 days). Comparison of HA-CDI in COVID-19 and non-COVID-19 patients indicates it occurs more frequently, in terms of CDI disease severity, COVID-19 does not seem to have a negative impact.
关于新型冠状病毒肺炎（COVID-19）患者感染艰难梭菌感染（CDI）的信息匮乏，且表明在疫情期间感染发作次数总体有所下降。这种情况显得自相矛盾，因为COVID-19患者住院时间长且抗生素使用频繁。我们进行了一项回顾性研究，时间跨度为2019年1月1日至2020年12月31日，比较了我院收治的有和没有COVID-19的患者中医院获得性CDI（HA-CDI）发作的发生率。在研究期间，2019年有47048例患者入院，2020年有35662例无COVID-19的患者入院，6763例COVID-19患者入院。COVID-19患者中有68例HA-CDI发作（14.75/10000天），2020年非COVID-19患者中有159例（5.54/10000天），2019年有238例（6.80/10000天）。COVID-19患者与非COVID-19患者HA-CDI的比较表明，就CDI疾病严重程度而言，HA-CDI在COVID-19患者中更频繁发生，但COVID-19似乎没有负面影响。
