Department of Mechanical Engineering, University of Houston, Houston, TX, 77204, USA.
Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA.
Small. 2022 Sep;18(36):e2107099. doi: 10.1002/smll.202107099. Epub 2022 Feb 19.
The need to develop wearable devices for personal health monitoring, diagnostics, and therapy has inspired the production of innovative on-demand, customizable technologies. Several of these technologies enable printing of raw electronic materials directly onto biological organs and tissues. However, few of them have been thoroughly investigated for biocompatibility of the raw materials on the cellular, tissue, and organ levels or with different cell types. In addition, highly accurate multiday in vivo monitoring using such on-demand, in situ fabricated devices has yet to be done. Presented herein is the first fully biocompatible, on-skin fabricated electronics for multiple cell types and tissues that can capture electrophysiological signals with high fidelity. While also demonstrating improved mechanical and electrical properties, the drawn-on-skin ink retains its properties under various writing conditions, which minimizes the variation in electrical performance. Furthermore, the drawn-on-skin ink shows excellent biocompatibility with cardiomyocytes, neurons, mice skin tissue, and human skin. The high signal-to-noise ratios of the electrophysiological signals recorded with the DoS sensor over multiple days demonstrate its potential for personalized, long-term, and accurate electrophysiological health monitoring.
需要开发可穿戴设备用于个人健康监测、诊断和治疗，这激发了创新的按需定制技术的产生。其中有几种技术能够将原始电子材料直接打印到生物器官和组织上。然而，很少有技术对原材料在细胞、组织和器官水平上的生物相容性进行过彻底的研究，也很少有技术针对不同的细胞类型进行过研究。此外，使用这种按需、原位制造的设备进行高精度、多天的体内监测还尚未完成。本文介绍了第一个完全生物相容的、可用于多种细胞类型和组织的皮肤内制造电子产品，它可以高保真地捕获电生理信号。在展示出更好的机械和电气性能的同时，绘制在皮肤上的墨水在各种书写条件下都能保持其性能，从而最大限度地减少了电气性能的变化。此外，绘制在皮肤上的墨水与心肌细胞、神经元、小鼠皮肤组织和人皮肤表现出极好的生物相容性。DoS 传感器记录的电生理信号具有较高的信噪比，这表明它在个性化、长期和准确的电生理健康监测方面具有潜力。
