胎盘表观基因组-大脑轴：胎盘表观基因组和转录组的反应预先编程认知障碍。
The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment.
机构信息
Department of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Institute for Environmental Health Solutions, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Epigenomics. 2022 Aug;14(15):897-911. doi: 10.2217/epi-2022-0061. Epub 2022 Sep 8.
Abstract
The placenta-brain axis reflects a developmental linkage where disrupted placental function is associated with impaired neurodevelopment later in life. Placental gene expression and the expression of epigenetic modifiers such as miRNAs may be tied to these impairments and are understudied. The expression levels of mRNAs (n = 37,268) and their targeting miRNAs (n = 2083) were assessed within placentas collected from the ELGAN study cohort (n = 386). The ELGAN adolescents were assessed for neurocognitive function at age 10 and the association with placental mRNA/miRNAs was determined. Placental mRNAs related to inflammatory and apoptotic processes are under miRNA control and associated with cognitive impairment at age 10. Findings highlight key placenta epigenome-brain relationships that support the developmental origins of health and disease hypothesis.
摘要
胎盘-大脑轴反映了一种发育联系，其中胎盘功能障碍与生命后期的神经发育受损有关。胎盘基因表达和表观遗传修饰因子（如 miRNA）的表达可能与这些损伤有关，但研究较少。在来自 ELGAN 研究队列的胎盘（n=386）中评估了 mRNA（n=37268）和其靶向 miRNA（n=2083）的表达水平。对 ELGAN 青少年在 10 岁时的神经认知功能进行了评估，并确定了与胎盘 mRNA/miRNA 的关联。与炎症和凋亡过程相关的胎盘 mRNA 受到 miRNA 的控制，并与 10 岁时的认知障碍有关。研究结果突出了关键的胎盘表观基因组-大脑关系，支持健康和疾病起源的发育假说。
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