Analytical Research Department, Soda Aromatic Co., Ltd., 1573-4 Funakata, Noda, Chiba Japan.
SANKEN, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka Japan.
Biosci Biotechnol Biochem. 2022 Oct 20;86(11):1562-1569. doi: 10.1093/bbb/zbac147.
Most of the odors that humans perceive daily are complex odors. It is believed that the modulation, enhancement, and suppression of overall complex odors are caused by interactions between odor molecules. In this study, to understand the interaction between odor molecules at the level of human olfactory receptor responses, the effects of 3-octen-2-one, which has been shown to modulate vanilla flavors, were analyzed using a human olfactory receptor sensor that uses all human olfactory receptors (388 types) as sensing molecules. As a result, the response intensity of 1 common receptor (OR1D2) was synergistically enhanced in vanilla flavor with 3-octen-2-one compared with vanilla flavor, and the response of 1 receptor (OR5K1) to vanilla flavor was completely suppressed. These results strongly suggested that the response of human olfactory receptors to complex odors is enhanced or suppressed by relatively few other odor molecules.
人类日常感知的大多数气味都是复杂气味。据认为，整体复杂气味的调制、增强和抑制是由气味分子之间的相互作用引起的。在这项研究中，为了在人类嗅觉受体反应水平上了解气味分子之间的相互作用，使用使用所有人类嗅觉受体（388 种）作为感应分子的人类嗅觉受体传感器分析了已显示能调节香草味的 3-辛烯-2-酮的作用。结果表明，与香草味相比，3-辛烯-2-酮使 1 种共同受体（OR1D2）对香草味的响应强度协同增强，而 1 种受体（OR5K1）对香草味的响应完全受到抑制。这些结果强烈表明，相对较少的其他气味分子增强或抑制了人类嗅觉受体对复杂气味的反应。
