Department of Population Health Sciences, School of Life Course and Population Sciences, King's College London, London, UK.
Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
J Gerontol A Biol Sci Med Sci. 2022 Dec 29;77(12):2453-2458. doi: 10.1093/gerona/glac182.
This study aimed to determine trajectories of depressive symptoms among older adults in England, overall and for those with hip fracture. The study aimed to explore the differential characteristics of each trajectory identified.
Analysis of adults aged 60 years or more (n = 7 050), including a hip fracture subgroup (n = 384), from the English Longitudinal Study of Ageing. Latent class growth mixture modeling was completed. Depressive symptom prevalence was estimated at baseline. Chi-square tests were completed to compare baseline characteristics across trajectories.
Three trajectories of depressive symptoms (no, mild, and moderate-severe) were identified overall and for those with hip fracture. The moderate-severe trajectory comprised 13.7% and 7% of participants for overall and hip fracture populations, respectively. The proportion of participants with depressive symptoms in the moderate-severe trajectory was 65.4% and 85.2% for overall and hip fracture populations, respectively. Depressive symptoms were stable over time, with a weak trend toward increasing severity for the moderate-severe symptom trajectory. Participants in the moderate-severe symptom trajectory were older, more likely to be female, live alone, and had worse health measures than other trajectories (p < .001).
Older adults, and those with hip fracture, follow one of the 3 trajectories of depressive symptoms that are broadly stable over time. Depressive symptoms' prevalence was higher for those with hip fracture and, when present, the symptoms were more severe than the overall population. Results suggest a role of factors including age, gender, and marital status in depressive symptom trajectories.
本研究旨在确定英国老年人总体及髋部骨折患者抑郁症状的轨迹,并探讨所确定的每个轨迹的差异特征。
对年龄在 60 岁及以上(n = 7050)的成年人(包括髋部骨折亚组 n = 384)进行分析,来自英国老龄化纵向研究。完成潜在类别增长混合模型分析。在基线时估计抑郁症状的患病率。完成卡方检验比较各轨迹的基线特征。
总体及髋部骨折患者均确定了 3 种抑郁症状轨迹(无、轻度和中重度)。中重度轨迹占总体和髋部骨折人群的 13.7%和 7%。中重度轨迹中患有抑郁症状的参与者比例分别为总体和髋部骨折人群的 65.4%和 85.2%。抑郁症状随时间稳定,中重度症状轨迹的严重程度呈微弱上升趋势。中重度症状轨迹的参与者年龄较大,女性比例较高,独居,健康指标较其他轨迹差(p <.001)。
老年人,以及髋部骨折患者,遵循 3 种抑郁症状轨迹中的一种,这些轨迹随时间基本稳定。髋部骨折患者的抑郁症状患病率更高,而且如果存在,其症状比总体人群更严重。结果表明,年龄、性别和婚姻状况等因素在抑郁症状轨迹中起作用。