IA类、IB类和IC类抗心律失常药物对豚鼠窦房结的不同电生理效应。
Differing electrophysiological effects of class IA, IB and IC antiarrhythmic drugs on guinea-pig sinoatrial node.
作者信息
Campbell T
出版信息
Br J Pharmacol. 1987 Jun;91(2):395-401. doi: 10.1111/j.1476-5381.1987.tb10294.x.
Abstract
Standard microelectrode techniques were used to study the effects of class IA (quinidine, disopyramide, procainamide), IB (lignocaine, mexiletine, tocainide) and IC (flecainide, encainide, lorcainide) antiarrhythmic drugs on action potentials in spontaneously beating sino-atrial node cells from guinea-pigs. The IA drugs all produced significant slowing of spontaneous rate in therapeutic concentrations. The IB agents did so only in concentrations well above therapeutic levels and the IC drugs were of intermediate potency. All nine drugs markedly slowed the repolarization rate and this was the major mechanism of sinus slowing for the IA and IC compounds. The IB drugs shared this effect but prolongation of phase 4 by reduction of the slope of diastolic depolarization was also a prominent feature of their action.
摘要
采用标准微电极技术研究ⅠA类（奎尼丁、双异丙吡胺、普鲁卡因胺）、ⅠB类（利多卡因、美西律、妥卡尼）和ⅠC类（氟卡尼、恩卡尼、劳卡尼）抗心律失常药物对豚鼠自发搏动的窦房结细胞动作电位的影响。ⅠA类药物在治疗浓度时均能显著减慢自发频率。ⅠB类药物仅在远高于治疗水平的浓度时才会如此，而ⅠC类药物的作用强度介于两者之间。所有九种药物均显著减慢复极速率，这是ⅠA类和ⅠC类化合物导致窦性心动过缓的主要机制。ⅠB类药物也有此作用，但通过降低舒张期去极化斜率来延长4期也是其作用的一个突出特点。
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