可乐定对犬肾上腺髓质分泌作用的研究。
A study of the action of clonidine on secretion from the adrenal medulla in dogs.
作者信息
Anglade F, Dang Tran L, De Saint Blanquat G, Gaillard G, Michel-Damase C, Montastruc J L, Montastruc P, Rostin M, Tran M A
出版信息
Br J Pharmacol. 1987 Jul;91(3):481-6. doi: 10.1111/j.1476-5381.1987.tb11240.x.
The effects of clonidine on adrenal catecholamine (adrenaline and noradrenaline) secretion were investigated in chloralose-anaesthetized dogs. Intravenous administration of clonidine (10 and 20 micrograms kg-1) induced a decrease in both adrenal catecholamine secretion rates and cardiovascular parameters (blood pressure and heart rate). In contrast, a dose of 5 micrograms kg-1 was ineffective. Intracisternal clonidine (in a lower dose of 3 micrograms kg-1) also decreased adrenaline and noradrenaline release from the adrenal gland. Clonidine failed to modify adrenal catecholamine release evoked by electrical stimulation of the splanchnic nerve. These results demonstrate that clonidine decreases adrenaline release from the adrenal gland through a central and not a peripheral mechanism in dogs. This action might contribute to its antihypertensive effects.
在水合氯醛麻醉的犬中研究了可乐定对肾上腺儿茶酚胺（肾上腺素和去甲肾上腺素）分泌的影响。静脉注射可乐定（10和20微克/千克）可导致肾上腺儿茶酚胺分泌率和心血管参数（血压和心率）降低。相比之下，5微克/千克的剂量无效。脑池内注射可乐定（较低剂量为3微克/千克）也可减少肾上腺肾上腺素和去甲肾上腺素的释放。可乐定未能改变内脏神经电刺激引起的肾上腺儿茶酚胺释放。这些结果表明，在犬中可乐定通过中枢而非外周机制减少肾上腺肾上腺素的释放。这种作用可能有助于其降压效果。
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