Hornick Jason L, Webster Fleur, Dei Tos Angelo Paolo, Hemmings Chris, Miettinen Markku, Oda Yoshinao, Raut Chandrajit P, Rubin Brian P, Von Mehren Margaret, Wardelmann Eva, Fletcher Christopher D M
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
International Collaboration on Cancer Reporting, Sydney, NSW, Australia.
Histopathology. 2023 Feb;82(3):376-384. doi: 10.1111/his.14791. Epub 2022 Sep 20.
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and are among the most frequent sarcomas. Accurate diagnosis, classification, and reporting are critical for prognostication and patient management, including selection of appropriate targeted therapy. Here we report on international consensus-based datasets for the pathology reporting of biopsy and resection specimens of GIST. The datasets were produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of major international pathology and cancer organizations. An international expert panel consisting of pathologists, a surgical oncologist, and a medical oncologist produced a set of core and noncore data items for biopsy and resection specimens based on a critical review and discussion of current evidence. All professionals involved were subspecialized soft tissue tumour experts and affiliated with tertiary referral centres. Commentary was provided for each data item to explain its clinical relevance and the rationale for selection as a core or noncore element. Following international public consultation, the datasets, which include synoptic reporting guides, were finalized and ratified, and published on the ICCR website. These first international datasets for GIST are intended to promote high-quality, standardised pathology reporting. Their widespread adoption will improve consistency of reporting, facilitate multidisciplinary communication, and enhance comparability of data, all of which will ultimately help to improve the management of patients with GIST. All the ICCR datasets, including these on GIST, are freely available worldwide on the ICCR website (www.iccr-cancer.org/datasets).
胃肠道间质瘤（GISTs）是胃肠道最常见的间叶组织肿瘤，也是最常见的肉瘤之一。准确的诊断、分类和报告对于预后评估和患者管理至关重要，包括选择合适的靶向治疗。在此，我们报告基于国际共识的GIST活检和切除标本病理报告数据集。这些数据集是在国际癌症报告协作组织（ICCR）的支持下编制的，ICCR是一个由主要国际病理和癌症组织组成的全球联盟。一个由病理学家、外科肿瘤学家和医学肿瘤学家组成的国际专家小组，在对当前证据进行批判性审查和讨论的基础上，为活检和切除标本制定了一套核心和非核心数据项。所有参与的专业人员均为软组织肿瘤亚专科专家，并隶属于三级转诊中心。对每个数据项都提供了注释，以解释其临床相关性以及作为核心或非核心要素入选的理由。经过国际公众咨询后，这些包括大纲报告指南的数据集最终确定并获得批准，并在ICCR网站上发布。这些首个GIST国际数据集旨在促进高质量、标准化的病理报告。它们的广泛采用将提高报告的一致性，促进多学科交流，并增强数据的可比性，所有这些最终都将有助于改善GIST患者的管理。所有ICCR数据集，包括这些关于GIST的数据集，均可在ICCR网站（www.iccr-cancer.org/datasets）上在全球范围内免费获取。
