Organophosphonic Acid-Regulating Assembly of P-Sb Polyoxotungstate and Its Potential in Building a Dual-Signal Readout Electrochemical Aptasensor for Carcinogen Detection.

Template-directed assembly of giant cluster-based nanomaterials is an everlasting theme in cluster science. In this work, ethylenediamine tetramethylphosphonic acid [HEDTPA = (POCH(OH))CHN] and [B-α-SbWO] were, respectively, used as an organic template and an inorganic template to prepare an organophosphonic acid-regulating P-Sb-heteroatom-inserted polyoxotungstate aggregate [HN(CH)]NaH[CeWO(HEDTPA)SbWO][B-α-SbWO]·36HO (). Noteworthily, organophosphonic acid ligand not only works as an organic template leading to the assembly of a [HEDTPASbWO] building block but also further bridges the sandwich-type [CeWO(B-α-SbWO)] entity. To extend its potential application in electrochemical sensing properties, we prepared a three-dimensional @EGO composite (EGO = reduced graphene oxide functionalized by ethylenediamine) with porous architecture and a prominent conducting ability. Furthermore, the @EGO composite was explored as a modification material for glassy carbon electrodes to build a dual-signal readout electrochemical aptasensor for carcinogens, which shows much better detection performance for aflatoxin B1 compared with traditional single-signal biosensors.