Department of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.
Cell Tissue Res. 2022 Nov;390(2):131-140. doi: 10.1007/s00441-022-03684-z. Epub 2022 Sep 8.
Tendinopathy is a common tendon disorder that causes pain, loss of strength and function, and local inflammation mainly characterized by hypoxia, collagen degradation, and extracellular matrix (ECM) disorganization. Generally, ECM degradation and remodeling is tightly regulated; however, hyperactivation of matrix metalloproteases (MMPs) contributes to excessive collagenolysis under pathologic conditions resulting in tendon ECM degradation. This review article focuses on the production, function, and signaling of matrikines for tendon regeneration following injury with insights into the expression, tissue compliance, and cell proliferation exhibited by various matrikines. Furthermore, the regenerative properties suggest translational significance of matrikines to improve the outcomes post-injury by assisting with tendon healing.
腱病是一种常见的肌腱疾病，主要表现为疼痛、无力和功能丧失，伴有局部炎症，其特征主要为缺氧、胶原降解和细胞外基质（ECM）紊乱。一般情况下，ECM 的降解和重塑受到严格调控；然而，在病理条件下，基质金属蛋白酶（MMPs）的过度激活会导致胶原过度降解，从而导致肌腱 ECM 降解。本文综述了损伤后腱再生过程中基质小肽的产生、功能和信号转导，深入探讨了各种基质小肽的表达、组织顺应性和细胞增殖情况。此外，基质小肽的再生特性表明其在改善损伤后愈合结局方面具有转化意义，可通过辅助肌腱愈合来提高疗效。
