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医学营养治疗及其他管理减重术后低血糖的方法:基于团队的方法

Medical Nutrition Therapy and Other Approaches to Management of Post-bariatric Hypoglycemia: A Team-Based Approach.

作者信息

Patience Nicole, Sheehan Amanda, Cummings Cameron, Patti Mary Elizabeth

机构信息

Clinic Division, Joslin Diabetes Center, Inc, One Joslin Place, Boston, MA, 02215, USA.

Research Division, Joslin Diabetes Center, Boston, MA, USA.

出版信息

Curr Obes Rep. 2022 Dec;11(4):277-286. doi: 10.1007/s13679-022-00482-0. Epub 2022 Sep 8.

Abstract

PURPOSE OF REVIEW

This manuscript provides a review of post-bariatric hypoglycemia (PBH) with a special focus on the role of the registered dietitian-nutritionist (RDN) and medical nutrition therapy (MNT) recommendations as foundational for management.

RECENT FINDINGS

As the number of bariatric surgeries rises yearly, with 256,000 performed in 2019, PBH is an increasingly encountered late complication. Following Roux-en-Y (RYGB) or vertical sleeve gastrectomy (VSG), about 1/3 of patients report symptoms suggestive of at least mild postprandial hypoglycemia, with severe and/or medically confirmed hypoglycemia in 1-10%. Anatomical alterations, changes in GLP1 and other intestinally derived hormones, excessive insulin response, reduced insulin clearance, impaired counterregulatory hormone response to hypoglycemia, and other factors contribute to PBH. MNT is the cornerstone of multidisciplinary treatment, with utilization of personal continuous glucose monitoring to improve safety when possible. While many individuals require pharmacotherapy, there are no currently approved medications for PBH. Increasing awareness and identification of individuals at risk for or with PBH is critical given the potential impact on safety, nutrition, and quality of life. A team-based approach involving the individual, the RDN, and other clinicians is essential in providing ongoing assessment and individualization of MNT in the long-term management of PBH.

摘要

综述目的

本手稿对减重术后低血糖(PBH)进行综述,特别关注注册营养师(RDN)的作用以及医学营养治疗(MNT)建议作为管理基础的情况。

最新发现

随着每年减重手术数量的增加,2019年进行了256,000例,PBH是一种越来越常见的晚期并发症。在接受Roux-en-Y胃旁路术(RYGB)或垂直袖状胃切除术(VSG)后,约1/3的患者报告有提示至少轻度餐后低血糖的症状,1% - 10%的患者有严重和/或经医学确认的低血糖。解剖学改变、胰高血糖素样肽1(GLP1)和其他肠道衍生激素的变化、胰岛素反应过度、胰岛素清除率降低、对低血糖的反调节激素反应受损以及其他因素导致了PBH。MNT是多学科治疗的基石,尽可能利用个人连续血糖监测来提高安全性。虽然许多人需要药物治疗,但目前尚无批准用于PBH的药物。鉴于对安全性、营养和生活质量的潜在影响,提高对有PBH风险或患有PBH的个体的认识和识别至关重要。在PBH的长期管理中,采用包括个体、RDN和其他临床医生的团队方法对于持续评估和MNT的个体化至关重要。

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