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向大鼠尾状核-壳核微量注射γ-氨基丁酸拮抗剂甲磺酸荷包牡丹碱可预防杏仁核点燃癫痫发作。

Microinjections of the gamma-aminobutyrate antagonist, bicuculline methiodide, into the caudate-putamen prevent amygdala-kindled seizures in rats.

作者信息

Cavalheiro E A, Bortolotto Z A, Turski L

出版信息

Brain Res. 1987 May 19;411(2):370-2. doi: 10.1016/0006-8993(87)91089-4.

DOI:10.1016/0006-8993(87)91089-4
PMID:3607440
Abstract

We used amygdala-kindled seizures in rats to study the function of striatal gamma-aminobutyrate (GABA) in the regulation of the seizure threshold of the limbic forebrain. Microinjections of the GABAA antagonist, bicuculline methiodide, 1 pmol, into the caudate-putamen protected rats against amygdala-kindled seizures. This result shows that striatal GABA differentially modulates the threshold for limbic seizures.

摘要

我们利用大鼠杏仁核点燃癫痫发作来研究纹状体γ-氨基丁酸（GABA）在调节边缘前脑癫痫发作阈值中的作用。向尾状核-壳核微量注射1皮摩尔的GABAA拮抗剂甲硫酸荷包牡丹碱，可保护大鼠免受杏仁核点燃癫痫发作的影响。这一结果表明，纹状体GABA对边缘性癫痫发作阈值具有差异性调节作用。

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Microinjections of the gamma-aminobutyrate antagonist, bicuculline methiodide, into the caudate-putamen prevent amygdala-kindled seizures in rats.向大鼠尾状核-壳核微量注射γ-氨基丁酸拮抗剂甲磺酸荷包牡丹碱可预防杏仁核点燃癫痫发作。
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