Yu Tiantian, Cai Qing-Qing, Zhai Qiong-Li, Li Ling, Fang Xiaosheng, Li Jianyong, Sun Ruifang, Yang Hanjin, Wang Zhaoming, Qian Wenbian, Xu-Monette Zijun Y, Young Ken H, Yu Li
Department of Hematology and Oncology, The Second Affiliated Hospital of NanChang University, Nanchang, China.
State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Leuk Lymphoma. 2022 Dec;63(13):3082-3091. doi: 10.1080/10428194.2022.2118528. Epub 2022 Sep 7.
As a rare lymphoproliferative disorder, many patients with HHV-8/HIV-negative Castleman disease (CD) have hypoalbuminemia. However, data is limited on whether hypoalbuminemia is an independent predictor of CD. We retrospectively collected data from 230 patients diagnosed at 12 medical centers in China and the U.S. Different classifications included 147 patients with unicentric CD (UCD) and 83 with idiopathic multicentric CD (iMCD). Adjusted smooth curve fitting showed that the relationship between albumin and all-cause death of patients with CD and iMCD was linear. Cox proportional hazards regression modeling showed a negative association between the risk of death and albumin level (hazard ratio [HR]: 0.84; 95% CI, 0.76, 0.93). Using the Kaplan-Meier method, we determined that hypoproteinemia was a risk factor for poorer prognosis in patients with CD, UCD, and iMCD. Albumin was independently and negatively associated with the risk of death in CD patients, especially those with iMCD.
作为一种罕见的淋巴增生性疾病，许多HHV-8/ HIV阴性的Castleman病（CD）患者存在低白蛋白血症。然而，关于低白蛋白血症是否为CD的独立预测因素的数据有限。我们回顾性收集了来自中国和美国12个医学中心诊断的230例患者的数据。不同分类包括147例单中心CD（UCD）患者和83例特发性多中心CD（iMCD）患者。调整后的平滑曲线拟合显示，白蛋白与CD和iMCD患者全因死亡之间的关系呈线性。Cox比例风险回归模型显示死亡风险与白蛋白水平呈负相关（风险比[HR]：0.84；95%置信区间，0.76，0.93）。使用Kaplan-Meier方法，我们确定低蛋白血症是CD、UCD和iMCD患者预后较差的危险因素。白蛋白与CD患者尤其是iMCD患者的死亡风险独立且呈负相关。
