Sørensen T, Finsen B, Zimmer J
Brain Res. 1987 Jun 16;413(2):392-7. doi: 10.1016/0006-8993(87)91036-5.
Fascia dentata tissue from embryonic mice was grafted to the hippocampal region of newborn Kyoto rats. After 1-7 months the recipients received lesions of the entorhinal cortex on the side of transplantation. Three days later their brains were processed for electron microscopy. The xenografts were identified by their content of mouse dentate granule cells which have smaller cell nuclei with more nucleoli than the corresponding host rat granule cells. Electron dense, degenerating host rat entorhinal fibers terminated in the outer parts of the mouse dentate molecular layer corresponding to the normal perforant path zones. They formed the normal type of synaptic contacts with dendritic spines. The findings demonstrate that precise synaptic contacts can be made across a species barrier.
将来自胚胎小鼠的齿状筋膜组织移植到新生京都大鼠的海马区。1至7个月后，受体大鼠接受移植侧内嗅皮质损伤。三天后，对它们的大脑进行电子显微镜处理。通过小鼠齿状颗粒细胞的含量来识别异种移植物，这些细胞的细胞核比相应的宿主大鼠颗粒细胞更小，核仁更多。电子致密的、正在退化的宿主大鼠内嗅纤维终止于小鼠齿状分子层的外部，对应于正常的穿通通路区域。它们与树突棘形成了正常类型的突触联系。这些发现表明，跨物种屏障可以形成精确的突触联系。
