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住院全髋关节和膝关节置换术后逐渐减量的阿片类药物处方:质量改进研究与回顾性分析

Tapered Dose Postoperative Opioid Prescriptions Following Inpatient Total Hip and Knee Arthroplasty: Quality Improvement Study and Retrospective Review.

作者信息

Kukushliev Vasil V, Sherman Katherine A, Kurylo Christopher M, Ortmann Stephen D, Scheidt Robert A, Scheidt Karl B

机构信息

Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin; Medical College of Wisconsin, Milwaukee, Wisconsin.

Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin.

出版信息

J Arthroplasty. 2023 Feb;38(2):239-244. doi: 10.1016/j.arth.2022.08.043. Epub 2022 Sep 6.

DOI:10.1016/j.arth.2022.08.043
PMID:36075313
Abstract

BACKGROUND

Overprescription of pain medications directly fuels the opioid epidemic. Veterans are profoundly impacted. Tapered dose protocols may reduce excessive prescribing.

METHODS

A retrospective study of adult veterans who presented to our institution for primary total knee arthroplasty or total hip arthroplasty (THA) was performed. Postdischarge opioid use was reviewed before and after an opioid taper prescription protocol. The preprotocol and postprotocol groups had 299 and 89 veterans, respectively. Total Morphine Milligram Equivalent (MME) prescribed postdischarge, number of tablets prescribed, number of refills issued, 30-day emergency department visits, and 30-day readmissions were compared. Opioid naïve and chronic opioid users were both included.

RESULTS

Preprotocol and postprotocol implementation group, in combination with surgery type (total knee arthroplasty versus THA) and opioid naïve status, predicted MME. On average, the postprotocol group received 224 MME less, THA patients received 177 MME less, and nonopioid naïve patients received 152 MME more.

CONCLUSION

The opioid taper protocol led to less opioid administration after discharge. Taper protocols should be considered for postoperative pain management.

LEVEL OF EVIDENCE

III, retrospective comparison study.

摘要

背景

止痛药的过度处方直接助长了阿片类药物流行。退伍军人受到了深远影响。逐渐减量的给药方案可能会减少过度处方。

方法

对到我们机构接受初次全膝关节置换术或全髋关节置换术(THA)的成年退伍军人进行了一项回顾性研究。在阿片类药物逐渐减量处方方案实施前后,对出院后阿片类药物的使用情况进行了回顾。方案实施前和实施后两组分别有299名和89名退伍军人。比较了出院后开具的吗啡毫克当量(MME)总量、开具的药片数量、发放的续方数量、30天内急诊就诊次数和30天内再入院情况。未使用过阿片类药物的患者和长期使用阿片类药物的患者均纳入研究。

结果

方案实施前和实施后组,结合手术类型(全膝关节置换术与THA)和未使用过阿片类药物的状态,可预测MME。平均而言,方案实施后组少接受224 MME,THA患者少接受177 MME,非未使用过阿片类药物的患者多接受152 MME。

结论

阿片类药物逐渐减量方案导致出院后阿片类药物使用减少。术后疼痛管理应考虑采用逐渐减量方案。

证据级别

III级,回顾性比较研究。

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