Institute of Technology, Faculty of Science and Technology, University of Tartu, Tartu, Estonia.
High Performance Computing Center, Institute of Computer Science, Faculty of Science and Technology, University of Tartu, Tartu, Estonia.
Int J Infect Dis. 2022 Nov;124:41-44. doi: 10.1016/j.ijid.2022.08.027. Epub 2022 Sep 6.
Despite the high number of SARS-CoV-2 infections, only a few cases of dual infection have been reported. Here, we describe a case of COVID-19 caused simultaneously by Delta and Omicron variants in an immunocompetent individual during the early emergence of Omicron variant. A 73-year-old man was hospitalized with suspected acute coronary syndrome and a positive test result for SARS-CoV-2 RNA was received during routine testing at the hospital. He experienced mild symptoms of COVID-19 and was discharged on the ninth day. We sequenced the SARS-CoV-2 whole genome from the sample obtained on admission. The viral sequence was classified as PANGO lineage B.1.1.10 by the Galaxy pipeline; however, on detailed manual analysis, we identified the presence of both Delta and Omicron variants. After excluding the possibilities of a recombinant virus or contamination in the sample, we confirmed the presence of dual infection in this patient. We highlight that dual infections with SARS-CoV-2 may be more common than expected but are difficult to detect during the waves of one dominant variant.
尽管有大量的 SARS-CoV-2 感染病例，但仅报告了少数几例双重感染病例。在这里，我们描述了一例免疫功能正常的个体在奥密克戎变异早期同时感染德尔塔和奥密克戎变异株的 COVID-19 病例。一名 73 岁男性因疑似急性冠状动脉综合征住院，在医院常规检测中收到 SARS-CoV-2 RNA 检测阳性结果。他出现了轻微的 COVID-19 症状，在第九天出院。我们从入院时获得的样本中对 SARS-CoV-2 全基因组进行了测序。病毒序列通过 Galaxy 管道被分类为 PANGO 谱系 B.1.1.10；然而，在详细的手动分析中，我们发现同时存在德尔塔和奥密克戎变异株。在排除样本中存在重组病毒或污染的可能性后，我们确认了该患者存在双重感染。我们强调，SARS-CoV-2 的双重感染可能比预期更为常见，但在一种主要变异株流行期间很难检测到。
