State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
Department of Obstetrics and Gynecology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong, China.
Int J Hyperthermia. 2022;39(1):1164-1169. doi: 10.1080/02656736.2022.2107716.
To investigate the relationship between preoperative CA125 and symptom recurrence in adenomyosis after ultrasound-guided high-intensity focused ultrasound ablation surgery (FUAS).
A total of 502 adenomyosis patients after FUAS in Affiliated Nanchong Central Hospital of North Sichuan Medical College from June 2017 to March 2021 were reviewed. Factors associated with symptom recurrence of adenomyosis were analyzed by binary logistic regression model. ROC was used to determine the optimal cutpoint. Magnitude of preoperative CA125 relating to timing of symptom recurrence was measured by cox regression and Kaplan-Meier (K-M) curves. Besides, multiple liner regression model was used to identify the impacting factors for preoperative CA125.
Multiple binary logistic analysis showed preoperative CA125 was related to symptom recurrence (OR = 1.002, 95%: 1.000～1.004, = 0.043). The ROC of preoperative CA125 for recurrence validated 35 U/ml had a high sensitivity (82.5%). Preoperative CA125 was related to timing of symptom recurrence (HR = 2.255, 95%: 1.387-3.667, = 0.001). K-M curves showed medium recurrence time in preoperative CA125 level >35 U/ml group (38.5 months) was shorter than that in CA125 level ≤35 U/ml group (44.5 months) ( = 0.001). Multiple liner regression analyses showed uterus volume and adenomyotic lesions volume positively correlated to preoperative CA125 level, while age negatively correlated to preoperative CA125 level.
The higher level of preoperative CA125 was related to an earlier onset of symptom recurrence after FUAS.
探讨超声引导高强度聚焦超声消融术（FUAS）治疗后子宫腺肌病患者术前 CA125 与症状复发的关系。
回顾性分析 2017 年 6 月至 2021 年 3 月川北医学院附属医院接受 FUAS 治疗的 502 例子宫腺肌病患者的临床资料，采用二项 logistic 回归模型分析与子宫腺肌病症状复发相关的因素，采用 ROC 确定最佳截断值。采用 cox 回归和 Kaplan-Meier（K-M）曲线分析术前 CA125 与症状复发时间的关系，采用多元线性回归模型分析术前 CA125 的影响因素。
多因素二项 logistic 分析显示，术前 CA125 与症状复发有关（OR=1.002，95%CI：1.000～1.004， = 0.043）。术前 CA125 对复发的 ROC 验证 35 U/ml 具有较高的灵敏度（82.5%）。术前 CA125 与症状复发时间有关（HR=2.255，95%CI：1.387～3.667， = 0.001）。K-M 曲线显示，术前 CA125 水平>35 U/ml 组的中位复发时间（38.5 个月）短于 CA125 水平≤35 U/ml 组（44.5 个月）（ = 0.001）。多元线性回归分析显示，子宫体积和腺肌瘤体积与术前 CA125 水平呈正相关，而年龄与术前 CA125 水平呈负相关。
术前 CA125 水平越高，FUAS 后症状复发的时间越早。
