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[同步多中心骨肉瘤。一名10岁男孩的病例及文献综述]

[Synchronic multicentric osteosarcoma. A case in a 10 year old boy and review of the literature].

作者信息

Pérez-García Jesús, Velasco-Donado Osvaldo, Robles-Pérez Karoll

机构信息

Programa de Medicina, Universidad Libre, Barranquilla, Colombia; Centro Diagnóstico PATONORTE, Clínica General del Norte, Barranquilla, Colombia.

Centro Diagnóstico PATONORTE, Clínica General del Norte, Barranquilla, Colombia.

出版信息

Rev Esp Patol. 2022 Sep;55 Suppl 1:S11-S15. doi: 10.1016/j.patol.2020.10.001. Epub 2020 Dec 11.

Abstract

The osteosarcoma is a malignant neoplasm originating in bone-producing cells whose usual presentation is predominantly monostotic in long bones. The polyostotic expression is rare, variable and controversial, predominantly high-grade cellular lesions in children; low-grade lesions that affect long bones in adults and others that show a dominant lesion in long bones from which metastases arise. We present the case of a ten-year-old patient with painful tumors in metaphasis and diaphysis of the femur, tibia, fibula, clavicle, humerus, as well as in pelvis, vertebrae and base of the skull of synchronous appearance with blindness. Diagnosis was made through X-ray images, CT scan, magnetic resonance imaging (MRI), and incisional biopsy of the femur. Evidenced of absence of neoplastic manifestation in lung imaging, at the time of pathological diagnosis. Histological findings revealed a high-grade osteosarcoma.

摘要

骨肉瘤是一种起源于骨生成细胞的恶性肿瘤,其通常表现主要为长骨单发性。多骨受累的情况罕见、表现多样且存在争议,主要表现为儿童的高级别细胞病变;成人的低级别病变累及长骨,以及其他在长骨出现主要病变并发生转移的情况。我们报告一例10岁患者,其在股骨、胫骨、腓骨、锁骨、肱骨的干骺端和骨干,以及骨盆、椎骨和颅底出现同步的疼痛性肿瘤,并伴有失明。通过X线影像、CT扫描、磁共振成像(MRI)以及股骨切开活检做出诊断。在病理诊断时,肺部影像显示无肿瘤表现。组织学检查结果显示为高级别骨肉瘤。

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Intracortical osteosarcoma; two-year delay in diagnosis.皮质内骨肉瘤;诊断延迟两年。
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