Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 37005 České Budějovice, Czech Republic.
Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 37005 České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, 37005 České Budějovice, Czech Republic.
Trends Parasitol. 2022 Dec;38(12):1053-1067. doi: 10.1016/j.pt.2022.08.010. Epub 2022 Sep 6.
Translation in mitochondria is mediated by mitochondrial ribosomes, or mitoribosomes, complex ribonucleoprotein machines with dual genetic origin. Mitoribosomes in trypanosomatid parasites diverged markedly from their bacterial ancestors and other eukaryotic lineages in terms of protein composition, rRNA content, and overall architecture, yet their core functional elements remained conserved. Recent cryo-electron microscopy studies provided atomic models of trypanosomatid large and small mitoribosomal subunits and their precursors, making these parasites the organisms with the best-understood biogenesis of mitoribosomes. The structures revealed molecular mechanisms and players involved in the assembly of mitoribosomes not only in the parasites, but also in eukaryotes in general.
线粒体中的翻译是由线粒体核糖体（或线粒体核糖体）介导的，线粒体核糖体是一种具有双重遗传起源的复杂核糖核蛋白机器。在蛋白质组成、rRNA 含量和整体结构方面，锥虫寄生虫的线粒体核糖体与它们的细菌祖先和其他真核生物谱系明显不同，但它们的核心功能元件仍然保守。最近的冷冻电子显微镜研究提供了锥虫大型和小型线粒体核糖体亚基及其前体的原子模型，使这些寄生虫成为线粒体核糖体生物发生过程中研究最为透彻的生物体。这些结构揭示了参与线粒体核糖体组装的分子机制和参与者，不仅在寄生虫中，而且在一般的真核生物中也是如此。
