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Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells.

作者信息

Ni Shuaishuai, Liu Qian, Chen Xin, Ding Lele, Cai Lili, Mao Fei, Shi Donglei, Hoffman Robert M, Li Jian, Jia Lijun

机构信息

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 200032, Shanghai, China.

State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 200037, Shanghai, China.

出版信息

Signal Transduct Target Ther. 2022 Sep 9;7(1):313. doi: 10.1038/s41392-022-01128-2.

Abstract
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