长非编码 RNA FTX 在癌症进展中的生物学作用。
Biological role of long non-coding RNA FTX in cancer progression.
机构信息
Department of Oncology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China; Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
Department of Oncology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.
出版信息
Biomed Pharmacother. 2022 Sep;153:113446. doi: 10.1016/j.biopha.2022.113446. Epub 2022 Jul 22.
Long non-coding RNAs (LncRNAs) are involved in several types of cancer and participate actively in tumorigenesis and disease progression. LncRNA FTX is the transcription product of the FTX gene located at the X-inactivation center (Xic). LncRNA FTX has been shown to regulate cancer cell proliferation, migration, and aberrant metabolism, as well as increase tumor growth and metastasis in vivo. Herein, we summarized currently available research on the interaction between LncRNA FTX and associated molecules and signaling pathways in malignant tumors to better understand the biological roles of LncRNA FTX in cancer progression.
长非编码 RNA（lncRNAs）参与多种类型的癌症，并积极参与肿瘤发生和疾病进展。lncRNA FTX 是位于 X 失活中心（Xic）的 FTX 基因的转录产物。已经表明，lncRNA FTX 调节癌细胞增殖、迁移和异常代谢，并增加体内肿瘤生长和转移。在此，我们总结了目前关于 lncRNA FTX 与恶性肿瘤相关分子和信号通路相互作用的研究，以更好地了解 lncRNA FTX 在癌症进展中的生物学作用。
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