Health Service Center, Saitama University, Saitama-shi, Japan.
Neurol India. 2022 Jul-Aug;70(4):1668-1669. doi: 10.4103/0028-3886.355093.
Delayed neuropsychiatric sequelae (DNS), which are related to neuropsychiatric symptoms and severe sequelae, occur within a few days of recovery from acute poisoning. They may involve a slowly progressing demyelinating white matter lesion caused by carbon monoxide cytotoxicity; moreover, the involvement of immune mechanisms has been reported. However, there remains no established treatment or therapeutic gain factors. A 29-year-old man with DNS who experienced carbon monoxide poisoning underwent corticosteroid therapy with concomitant measurements of cerebrospinal fluid levels of MBP, IL-6, and pNF-H. Treatment led to an improvement in symptoms and lesions on magnetic resonance imaging. Corticosteroid therapy and monitoring can be used to treat and monitor DNS.
迟发性神经精神后遗症（DNS）与神经精神症状和严重后遗症有关，发生在急性中毒恢复后的几天内。它可能涉及由一氧化碳细胞毒性引起的缓慢进展的脱髓鞘白质病变；此外，已经报道了免疫机制的参与。然而，目前仍然没有确立的治疗或治疗获益因素。一名 29 岁的 DNS 患者因一氧化碳中毒接受了皮质类固醇治疗，并同时测量了脑脊液中 MBP、IL-6 和 pNF-H 的水平。治疗导致症状和磁共振成像上的病变改善。皮质类固醇治疗和监测可用于治疗和监测 DNS。
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