Wang Yongjing, Zhou Zunzhen, Zhang Dailiang, Jiang Yuan
Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Front Med (Lausanne). 2025 Mar 26;12:1559264. doi: 10.3389/fmed.2025.1559264. eCollection 2025.
Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is one of the severe complications that can occur after acute carbon monoxide poisoning (ACOP). The pathogenesis of DEACMP is complex, featuring a delitescence onset and poor prognosis. As a result, many scholars are concentrating on identifying predictors of DEACMP and evaluating their effects, including clinical characteristics, laboratory indicators, neuroelectrophysiology, imaging examination, and genetic susceptibility. However, current identified predictors lack consensus and their clinical application is limited. Therefore, we need to explore new predictors. Exosomes, the smallest extracellular vesicles (EVs) with nano-size, participate in both the physiological and pathological processes of the brain, and the changes in their content can provide valuable information for clinical diagnosis and evaluation of neurodegenerative diseases, suggesting that they may serve as a potential biomarker. However, the practicability of exosomes as biomarkers of DEACMP remains unclear. In the present review, we first introduced the pathogenesis of DEACMP and the currently identified predictors. Then, we also discussed the possibility of exosomes as the biomarkers of DEACMP, aiming to stimulate more attention and discussion on this topic, thereby providing meaningful insights for future research.
急性一氧化碳中毒后迟发性脑病（DEACMP）是急性一氧化碳中毒（ACOP）后可能发生的严重并发症之一。DEACMP的发病机制复杂，具有发病隐匿、预后不良的特点。因此，许多学者致力于确定DEACMP的预测指标并评估其作用，包括临床特征、实验室指标、神经电生理学、影像学检查和遗传易感性。然而，目前已确定的预测指标缺乏共识，其临床应用也受到限制。因此，我们需要探索新的预测指标。外泌体是最小的纳米级细胞外囊泡（EVs），参与大脑的生理和病理过程，其内容物的变化可为神经退行性疾病的临床诊断和评估提供有价值的信息，这表明它们可能作为一种潜在的生物标志物。然而，外泌体作为DEACMP生物标志物的实用性仍不明确。在本综述中，我们首先介绍了DEACMP的发病机制和目前已确定的预测指标。然后，我们还讨论了外泌体作为DEACMP生物标志物的可能性，旨在激发对该主题更多的关注和讨论，从而为未来的研究提供有意义的见解。
