Egea Mariana Buranelo, Pierce Gavin, Park Si-Hong, Lee Sang-In, Heger Fabienne, Shay Neil
Goiano Federal Institute, Campus Rio Verde, Rio Verde 75901-970, Brazil.
Departament of Food Science and Technology, Oregon State University, Corvallis, OR 97330, USA.
Foods. 2022 Aug 23;11(17):2543. doi: 10.3390/foods11172543.
The pseudofruit of Rizzini, "Cerrado" cashew pulp, has been described as rich in flavonoids, phenolic compounds, and vitamin C. The objective of this work was to evaluate the beneficial health effects seen with the addition of "Cerrado" cashew pulp (CP) to an obesogenic high fat diet provided to C57BL/6J male mice. In week 9, the HF-fed group had a significantly higher baseline glucose concentration than the LF- or HF+CP-fed groups. In RNAseq analysis, 4669 of 5520 genes were found to be differentially expressed. Among the genes most upregulated with the ingestion of the CP compared to HF were , , , and which are related to glucose homeostasis; that may be involved steroid biosynthetic process; and which has a role in the regulation of circadian rhythm. Although "Cerrado" CP intake did not cause changes in the food intake or body weight of fed mice with HF diet, carbohydrate metabolism appeared to be improved based on the observed changes in gene expression.
里齐尼的假果“塞拉多”腰果果肉，被描述为富含黄酮类化合物、酚类化合物和维生素C。这项工作的目的是评估在给C57BL/6J雄性小鼠提供的致肥胖高脂肪饮食中添加“塞拉多”腰果果肉（CP）所观察到的有益健康效果。在第9周时，高脂喂养组的基线血糖浓度显著高于低脂或高脂+CP喂养组。在RNA测序分析中，发现5520个基因中的4669个基因存在差异表达。与高脂组相比，摄入CP后上调最多的基因中， 、 、 和 与葡萄糖稳态相关； 可能参与类固醇生物合成过程； 则在昼夜节律调节中发挥作用。虽然摄入“塞拉多”CP并未导致高脂饮食喂养小鼠的食物摄入量或体重发生变化，但基于观察到的基因表达变化，碳水化合物代谢似乎得到了改善。
