Laboratory of Human and Medical Genetics, Graduate Program in Genetics and Molecular Biology, Federal University of Pará, Belém 66075-110, Brazil.
Int J Mol Sci. 2022 Aug 23;23(17):9511. doi: 10.3390/ijms23179511.
In humans, mitochondria play key roles in the regulation of cellular functions, such as the regulation of the innate immune response and are targets of several pathogenic viruses and bacteria. Mycobacteria are intracellular pathogens that infect cells important to the immune system of organisms and target mitochondria to meet their energy demands. In this review, we discuss the main mechanisms by which mitochondria regulate the innate immune response of humans to mycobacterial infection, especially those that cause tuberculosis and leprosy. Notably, the importance of mitochondrial haplogroups and ancestry studies for mycobacterial diseases is also discussed.
在人类中，线粒体在细胞功能的调节中发挥着关键作用，例如先天免疫反应的调节，并且是几种致病病毒和细菌的靶标。分枝杆菌是感染生物体免疫系统中重要细胞的细胞内病原体，它们靶向线粒体以满足其能量需求。在这篇综述中，我们讨论了线粒体调节人类对分枝杆菌感染的先天免疫反应的主要机制，特别是那些引起肺结核和麻风病的机制。值得注意的是，线粒体单倍群和祖先研究对分枝杆菌病的重要性也在讨论之中。
