Schäfer-Somi Sabine, Kaya Duygu, Aslan Selim
Platform for Artificial Insemination and Embryo Transfer, Vetmeduni Vienna, 1210 Vienna, Austria.
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Kafkas, 36100 Kars, Turkey.
Animals (Basel). 2022 Sep 1;12(17):2267. doi: 10.3390/ani12172267.
The search for an alternative approach of estrus control (induction or suppression) in dogs is an important issue and the use of slow GnRH agonist-releasing implants has been the subject of frequent research in recent years. Studies to date demonstrate that the short- and long-term effects of deslorelin implants applicated at different time points of the prepubertal period are similar to those of adult dogs; however, there are important differences. The age of the prepubertal bitch and the dosage appear to be the main determinants of the response to deslorelin, as well as the individual metabolism of the bitch. Recent studies reported that the deslorelin-mediated long-term delay of puberty does not have negative carry-over effects on subsequent ovarian functionality, serum steroid hormone concentrations, uterine health, and fertility; however, more molecular studies are needed to determine the effects of application time of GnRH agonists on hormone concentrations and peripheral receptor expression. Furthermore, the long-term effects of delay of puberty with deslorelin on joint health, tumor development, the immune system, and social behavior deserve further investigations.
寻找犬类发情控制（诱导或抑制）的替代方法是一个重要问题，近年来，使用缓释促性腺激素释放激素（GnRH）激动剂植入物一直是频繁研究的课题。迄今为止的研究表明，在青春期前不同时间点应用醋酸去甲雄三烯醇酮植入物的短期和长期效果与成年犬相似；然而，也存在重要差异。青春期前母犬的年龄和剂量似乎是对醋酸去甲雄三烯醇酮反应的主要决定因素，母犬的个体新陈代谢也是如此。最近的研究报告称，醋酸去甲雄三烯醇酮介导的青春期长期延迟对随后的卵巢功能、血清类固醇激素浓度、子宫健康和生育能力没有负面遗留影响；然而，需要更多的分子研究来确定GnRH激动剂应用时间对激素浓度和外周受体表达的影响。此外，醋酸去甲雄三烯醇酮延迟青春期对关节健康、肿瘤发展、免疫系统和社会行为的长期影响值得进一步研究。
