Havel M, Müller M, Graninger W, Kurz R, Lindemayr H
Clin Ther. 1987;9(4):373-9.
The efficacy and tolerability of a conventional vitamin K1 preparation containing polyoxyethylated castor oil as solubilizer were compared with those of a new compound containing mixed micelles as solubilizer in 30 patients. A statistically significant increase in the thrombotest was detected after treatment in both groups. No hematological or chemical toxicity was observed during the observation period. One patient had an anaphylactoid reaction after intravenous injection of the mixed micelles preparation. Intradermal testing yielded positive results. The authors conclude that intravenous administration of vitamin K preparations should be reserved for acute emergencies.
在30名患者中，对一种以聚氧乙烯蓖麻油作为增溶剂的传统维生素K1制剂与一种以混合微胶粒作为增溶剂的新化合物的疗效和耐受性进行了比较。两组治疗后均检测到凝血试验有统计学意义的增加。观察期间未观察到血液学或化学毒性。一名患者在静脉注射混合微胶粒制剂后发生类过敏反应。皮内试验结果呈阳性。作者得出结论，维生素K制剂的静脉给药应仅用于急性紧急情况。
