Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan.
Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan.
Int J Environ Res Public Health. 2022 Aug 27;19(17):10677. doi: 10.3390/ijerph191710677.
Oral dysfunction is related to long-term cares including activities of daily living. The objective of this study was to determine the association between oral function and the bone-related physiological substances osteocalcin (OC) and insulin-like growth factor-1 (IGF-1).
The study participants were 139 community-dwelling older people in Japan. Evaluation of oral dysfunction was based on subjective judgment by each participant. Blood analysis included OC, IGF-1, and albumin.
Univariate and multiple logistic analyses showed that IGF-1 was significantly associated with a "decline in masticatory function" ( = 0.0074 and = 0.0308, respectively). Receiver operating characteristic curve analysis of IGF-1 levels revealed a threshold score of 108 ng/mL ( < 0.01) for discriminating a "decline in masticatory function". Logistic regression analysis revealed that participants with an IGF-1 level ≤108 ng/mL had an odds ratio of 4.31 ( < 0.05) for a "decline in masticatory function". No significant association was found between the OC level and oral dysfunction.
These results suggest a possible relationship between lower serum IGF-1 levels and a decline in masticatory dysfunction in community-dwelling older people.
口腔功能与包括日常生活活动在内的长期护理有关。本研究的目的是确定口腔功能与骨相关生理物质骨钙素（OC）和胰岛素样生长因子-1（IGF-1）之间的关系。
本研究的参与者是日本的 139 名社区居住的老年人。口腔功能障碍的评估基于每个参与者的主观判断。血液分析包括 OC、IGF-1 和白蛋白。
单变量和多变量逻辑分析表明，IGF-1 与“咀嚼功能下降”显著相关（ = 0.0074 和 = 0.0308，分别）。IGF-1 水平的受试者工作特征曲线分析显示，108ng/mL（<0.01）的阈值评分可用于区分“咀嚼功能下降”。逻辑回归分析显示，IGF-1 水平≤108ng/mL 的参与者发生“咀嚼功能下降”的优势比为 4.31（<0.05）。OC 水平与口腔功能障碍之间无显著相关性。
这些结果表明，血清 IGF-1 水平较低与社区居住的老年人咀嚼功能障碍下降之间可能存在关系。
