Anastassiades T, Wood A, Elliott M, Stephens C, Kisilevsky R
Cell Differ. 1987 Jun;21(1):37-46. doi: 10.1016/0045-6039(87)90446-5.
A small molecular weight factor, derived from bovine bone ('matrigenin'), stimulated glycosaminoglycan and proteoglycan synthesis of cultured human fibroblastic cells but not of mononuclear cells from human blood. However, proteoglycan synthesis and secretion by the mononuclear cells was stimulated by the addition of concanavalin A. The proteoglycan from the concanavalin-A-stimulated mononuclear cells was of smaller molecular weight than the proteoglycan from the 'matrigenin'-stimulated fibroblastic cells. The major increase in proteoglycan synthesis and secretion occurred much later during the culture period for concanavalin-A-stimulated mononuclear cells than for 'matrigenin'-stimulated fibroblastic cells.
一种源自牛骨的小分子因子（“基质生成素”），可刺激培养的人成纤维细胞合成糖胺聚糖和蛋白聚糖，但对人血中的单核细胞无此作用。然而，添加伴刀豆球蛋白A可刺激单核细胞合成和分泌蛋白聚糖。伴刀豆球蛋白A刺激的单核细胞产生的蛋白聚糖分子量比“基质生成素”刺激的成纤维细胞产生的蛋白聚糖分子量小。伴刀豆球蛋白A刺激的单核细胞在培养期间蛋白聚糖合成和分泌的主要增加比“基质生成素”刺激的成纤维细胞晚得多。
