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食管癌胸腔镜食管切除术及纵隔淋巴结清扫术中喉返神经监测的临床结果

Clinical Outcome of Intraoperative Recurrent Laryngeal Nerve Monitoring during Thoracoscopic Esophagectomy and Mediastinal Lymph Node Dissection for Esophageal Cancer.

作者信息

Huang Chang-Lun, Chen Chun-Min, Hung Wei-Heng, Cheng Ya-Fu, Hong Ruei-Ping, Wang Bing-Yen, Cheng Ching-Yuan

机构信息

Division of Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, Changhua 500, Taiwan.

Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan.

出版信息

J Clin Med. 2022 Aug 23;11(17):4949. doi: 10.3390/jcm11174949.

Abstract

Mediastinal lymph dissection in esophagectomy for patients with esophageal cancer is important. The dissection of recurrent laryngeal nerve (RLN) lymph nodes could cause RLN injury, vocal cord palsy, pneumonia, and respiratory failure. This retrospective study aimed to evaluate the effects of intraoperative RLN monitoring in esophagectomy and mediastinal lymph node dissection in preventing RLN injury and vocal cord palsy. This study included 75 patients who underwent minimally invasive esophagectomy and mediastinal lymph node dissection for esophageal cancer with (38 patients) and without (37 patients) IONM at Changhua Christian Hospital from 2015 to 2020. The surgical and clinical outcomes were reviewed. Patients in the IONM group had more advanced clinical T status, shorter operation time (570 vs. 633 min, = 0.007), and less blood loss (100 mL vs. 150 mL, = 0.019). The IONM group had significantly less postoperative vocal palsy (10.5% vs. 37.8%, = 0.006) and pneumonia (13.2% vs. 37.8%, = 0.014) than that in the non-IONM group. IONM was an independent factor for less postoperative vocal cord palsy that was related to postoperative 2-year survival. This study demonstrated that IONM could reduce the incidence of postoperative vocal cord palsy and pneumonia.

摘要

食管癌患者行食管切除术中纵隔淋巴结清扫很重要。喉返神经(RLN)淋巴结清扫可能导致喉返神经损伤、声带麻痹、肺炎和呼吸衰竭。这项回顾性研究旨在评估术中喉返神经监测在食管切除术和纵隔淋巴结清扫中预防喉返神经损伤和声带麻痹的效果。本研究纳入了2015年至2020年在彰化基督教医院接受微创食管切除术和纵隔淋巴结清扫的75例食管癌患者,其中38例使用术中神经监测(IONM),37例未使用。回顾了手术和临床结果。IONM组患者的临床T分期更高,手术时间更短(570分钟对633分钟,P = 0.007),失血量更少(100毫升对150毫升,P = 0.019)。IONM组术后声带麻痹(10.5%对37.8%,P = 0.006)和肺炎(13.2%对37.8%,P = 0.014)的发生率明显低于非IONM组。IONM是术后声带麻痹较少的独立因素,这与术后2年生存率有关。本研究表明,IONM可降低术后声带麻痹和肺炎的发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8511/9456676/effe689afbd1/jcm-11-04949-g001.jpg

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