Allegrini Davide, Vezzola Diego, Borgia Alfredo, Raimondi Raffaele, Sorrentino Tania, Tripepi Domenico, Stradiotto Elisa, Alì Marco, Montesano Giovanni, Romano Mario R
Eye Clinic, Humanitas Gavazzeni-Castelli Hospital, Via Giuseppe Mazzini 11, 24128 Bergamo, Italy.
Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, 20089 Rozzano, Italy.
J Clin Med. 2022 Aug 26;11(17):5023. doi: 10.3390/jcm11175023.
Objective: The objective of this study was to analyze the status of the retinal pigment epithelium (RPE) by means of the spectral domain optical coherence tomography (SD-OCT) overlying the myopic neovascular lesions in the involutive phase, looking for any correlations between the status of the RPE and the size of the lesions and the type and duration of the treatment. Methods: SD-OCT examinations of 83 consecutive patients with myopic choroidal neovascularization (CNV) were reviewed and divided into two groups: group A, patients with CNV characterized by uniformity of the overlying RPE, and group B, patients with CNV characterized by non-uniformity of the overlying RPE. Results: The median lesion area, major diameter, and minimum diameter were, respectively, 0.42 mm2 (0.30−1.01 mm2), 0.76 mm2 (0.54−1.28 mm2), and 0.47 mm2 (0.63−0.77 mm2) in group A, and 1.60 mm2 (0.72−2.67 mm2), 1.76 mm2 (1.13−2.23 mm2), and 0.98 mm2 (0.65−1.33 mm2) in group B. These values were lower in group A than in group B (p < 0.001). The number of treatments with a period free of disease recurrence for at least 6 months was greater (p < 0.010) in group B (6.54 ± 2.82) than in group A (3.67 ± 2.08), and treatments include intravitreal anti-vascular endothelial growth factor injection, photodynamic therapy, or both. Conclusions: Our results showed that the size of myopic neovascular lesion influences the development of a uniform RPE above the lesion and therefore the disease prognosis. The presence of uniform RPE was found to be extremely important in the follow-up of patients with myopic CNV, as it influences the duration of the disease and the number of treatments required.
本研究旨在通过光谱域光学相干断层扫描（SD-OCT）分析退行期近视性新生血管病变上方视网膜色素上皮（RPE）的状况，寻找RPE状况与病变大小、治疗类型及持续时间之间的相关性。方法：回顾性分析83例连续的近视性脉络膜新生血管（CNV）患者的SD-OCT检查结果，并将其分为两组：A组，病变上方RPE均匀的CNV患者；B组，病变上方RPE不均匀的CNV患者。结果：A组病变的中位面积、长径和短径分别为0.42 mm²（0.30 - 1.01 mm²）、0.76 mm²（0.54 - 1.28 mm²）和0.47 mm²（0.63 - 0.77 mm²），B组分别为1.60 mm²（0.72 - 2.67 mm²）、1.76 mm²（1.13 - 2.23 mm²）和0.98 mm²（0.65 - 1.33 mm²）。A组的这些值低于B组（p < 0.001）。B组（6.54 ± 2.82）至少6个月无疾病复发的治疗次数多于A组（3.67 ± 2.08）（p < 0.010），治疗方法包括玻璃体内注射抗血管内皮生长因子、光动力疗法或两者联合。结论：我们的结果表明，近视性新生血管病变的大小影响病变上方均匀RPE的形成，进而影响疾病预后。发现均匀RPE的存在在近视性CNV患者的随访中极为重要，因为它影响疾病持续时间和所需治疗次数。
