Department of Commodity and Food Analysis, The Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, 10-726 Olsztyn, Poland.
USP-CEU Group of Excellence "Nutrition for Life", ref: E02/0720, Department of Health and Pharmaceutical Sciences, Faculty of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Montepríncipe Urbanization, 28660 Boadilla del Monte, Spain.
Nutrients. 2022 Aug 25;14(17):3500. doi: 10.3390/nu14173500.
One way of increasing folate status, especially in a state of increased demand (e.g., women of childbearing age), is dietary supplementation with folic acid (FA). The dietary supplements market in Poland shows a controversial situation and, for many reasons (the ease of placing them on the market, the lack of control of chemical composition), the possibility of inaccurate information provided on the supplement's label arises. We questioned whether FA supplements available in Poland are indeed complying with regulations and if they could actually improve folate status amongst the target population groups consuming them. Almost 500 products containing FA were identified and available for sale in pharmacies, all of them including specific information provided by manufacturers on the packaging, such as the amount of FA, their intended use and daily dosage. HPLC analysis of FA content in 30 randomly purchased supplements exposed that in four of the tested products, FA content was less than 4% of the declared value (DV). Another 11 samples exposed that the difference with declared FA content varied from 25% up to 80% of the DV. The obtained results are in agreement with the ones from inspections previously conducted on the Polish dietary supplements market and indicate the urgent need to implement improvements in the notification system as well as the monitorization of these product's authenticity.
增加叶酸状态的一种方法，特别是在需求增加的情况下（例如，育龄妇女），是通过膳食补充叶酸（FA）。波兰的膳食补充剂市场存在争议，由于许多原因（易于上市、缺乏化学成分控制），补充剂标签上可能会出现不准确的信息。我们质疑波兰提供的 FA 补充剂是否确实符合法规，以及它们是否真的可以改善服用它们的目标人群的叶酸状态。在药店中发现了近 500 种含有 FA 的产品并可供销售，所有这些产品都在包装上提供了制造商提供的特定信息，例如 FA 的含量、用途和每日剂量。对 30 种随机购买的补充剂中的 FA 含量进行 HPLC 分析表明，在测试的四种产品中，FA 含量低于宣称值（DV）的 4%。另外 11 个样本表明，与宣称的 FA 含量的差异从 DV 的 25%到 80%不等。所得结果与之前对波兰膳食补充剂市场进行的检查结果一致，表明迫切需要改进通知系统，并对这些产品的真实性进行监测。
