维生素 D 补充与 COVID-19 结局：越来越多的证据，越来越少的疑问。
Vitamin D Supplementation and COVID-19 Outcomes: Mounting Evidence and Fewer Doubts.
机构信息
IRCCS AziendaOspedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40100 Bologna, Italy.
出版信息
Nutrients. 2022 Aug 31;14(17):3584. doi: 10.3390/nu14173584.
Abstract
The coronavirus disease 2019 (COVID-19) has already killed more than 6 million people around the world. A growing body of epidemiological evidence suggests that low 25-hydroxy vitamin D (25-OH-vitamin D) plasma levels are associated with an increased risk of developing COVID-19 and -most importantly-with a higher risk of developing more severe COVID-19 and dying. On the other hand, vitamin D supplementation during the early phases of COVID-19 has been related to a decreased length of hospital stay, less frequent need for oxygen, and a reduced mortality rate in inpatients. This seems to be particularly true when high dosages are used. In light of this evidence, further studies are needed to define the best timing for vitamin D supplementation and the most effective dosage schedule.
摘要
新型冠状病毒病 2019（COVID-19）已在全球造成超过 600 万人死亡。越来越多的流行病学证据表明，血浆中低 25-羟维生素 D（25-OH-维生素 D）水平与患 COVID-19 的风险增加有关，且更重要的是，与患更严重 COVID-19 和死亡的风险增加有关。另一方面，COVID-19 早期补充维生素 D 与住院时间缩短、氧气需求减少以及住院患者死亡率降低有关。当使用高剂量时，这种情况似乎尤其如此。鉴于这一证据，需要进一步研究以确定维生素 D 补充的最佳时机和最有效的剂量方案。
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