College of Economics and Management, China Agricultural University, Beijing 100083, China.
Academy of Global Food Economics and Policy, China Agricultural University, Beijing 100083, China.
Nutrients. 2022 Aug 31;14(17):3596. doi: 10.3390/nu14173596.
Alcohol consumption has been associated with the risk of mild cognitive impairment (MCI) in observational studies. The result is inconsistent and whether the association is causal remains unknown. To examine the causal effect of alcohol consumption on MCI in rural China, this study used a cross-sectional dataset that included 1966 observations collected in rural China, of which 235 observations' genotyping were collected. All participants accepted the MCI evaluation using Mini-Cog and were asked about the participants' alcohol consumption behavior. The causal effect of alcohol consumption on MCI was investigated by Mendelian randomization (MR) of genetic variation in the aldehyde dehydrogenase 2 ( rs671) gene. The risk of MCI in Chinese rural areas was 43%. Alcohol consumption was causally associated with a higher risk of MCI under MR design. Parameter estimates of drinking or not ( = 0.271, = 0.007, 95% CI = 0.073 to 0.469), drinking frequency during the past 30 days ( = 0.016, = 0.003, 95% CI = 0.005 to 0.027), and the weekly ethanol consumption ( = 0.132, = 0.004, 95% CI = 0.042 to 0.223) were all positive and statistically significant at the 5% level. In conclusion, there was a high risk of MCI in rural China, and alcohol consumption was causally associated with a higher risk of MCI.
饮酒与观察性研究中的轻度认知障碍（MCI）风险相关。但结果并不一致，并且这种关联是否具有因果关系仍不清楚。为了在中国农村研究饮酒对 MCI 的因果效应，本研究使用了一个包含 1966 个观测值的横断面数据集，其中 235 个观测值的基因型被采集。所有参与者都接受了 Mini-Cog 的 MCI 评估，并被问及参与者的饮酒行为。通过乙醛脱氢酶 2 （rs671）基因的遗传变异的孟德尔随机化（MR）来研究饮酒对 MCI 的因果效应。中国农村地区的 MCI 风险为 43%。在 MR 设计下，饮酒与 MCI 风险增加存在因果关系。饮酒或不饮酒的参数估计（ = 0.271， = 0.007，95%置信区间= 0.073 至 0.469）、过去 30 天的饮酒频率（ = 0.016， = 0.003，95%置信区间= 0.005 至 0.027）和每周乙醇摄入量（ = 0.132， = 0.004，95%置信区间= 0.042 至 0.223）均为正值且在 5%水平上具有统计学意义。总之，中国农村地区 MCI 的风险较高，饮酒与 MCI 风险增加具有因果关系。
