Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea.
Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea.
J Korean Med Sci. 2021 Aug 2;36(30):e195. doi: 10.3346/jkms.2021.36.e195.
Several studies have reported conflicting results regarding the relationship between alcohol consumption and cortisol levels. However, the causality between alcohol consumption and cortisol levels has not been evaluated.
This study examined 8,922 participants from the Dong-gu Study. The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was used as an instrumental variable for alcohol consumption. The association between the genetically predicted alcohol consumption and cortisol level was evaluated with Mendelian randomization (MR) using two-stage least squares regression.
Alcohol consumption was positively associated with the serum cortisol level in both sexes in the observational analysis. In the MR analysis, the genetically predicted alcohol consumption was positively related to the cortisol level in men, with cortisol levels increasing by 0.18 μg/dL per drink per day. However, there was no relationship in women in the MR analysis.
The predicted alcohol consumption according to the ALDH2 rs671 polymorphism was positively related to the cortisol levels, suggesting a causal relationship between alcohol consumption and cortisol levels.
多项研究报告了饮酒与皮质醇水平之间的关系存在矛盾的结果。然而，饮酒与皮质醇水平之间的因果关系尚未得到评估。
本研究调查了来自东九研究的 8922 名参与者。乙醛脱氢酶 2（ALDH2）rs671 多态性被用作饮酒的工具变量。使用两阶段最小二乘法回归，通过孟德尔随机化（MR）评估遗传预测的饮酒量与皮质醇水平之间的关联。
在观察性分析中，饮酒与两性的血清皮质醇水平呈正相关。在 MR 分析中，根据 ALDH2 rs671 多态性预测的饮酒与男性的皮质醇水平呈正相关，每天每饮酒增加 0.18μg/dL。然而，在 MR 分析中，女性没有相关性。
根据 ALDH2 rs671 多态性预测的饮酒量与皮质醇水平呈正相关，表明饮酒与皮质醇水平之间存在因果关系。
