Li Weihua, Wang Yingying, Li Wenwen, Liu Lei, Wang Xiao, Song Shiyong
Orthopedics Department, Huaihe Hospital of Henan University, Kaifeng 475001, China.
School of Pharmacy, Henan University, Kaifeng 475004, China.
Polymers (Basel). 2022 Aug 25;14(17):3485. doi: 10.3390/polym14173485.
Premature failure caused by inadequate lubrication of an artificial joint is a major problem. Inspired by engine lubrication, in which various additives are used to enforce the oil lubricant, here, a bench test of a biomimetic lubricating fluid containing different substances was carried out. Bovine serum albumin (BSA), in the form of both molecules and nanoparticles, was used as a functional additive. Compared with BSA molecules, BSA nanoparticles dispersed in HA solution served as more effective additives in the biomimetic lubrication fluid to minimize the friction and wear of ceramic orthopedic materials made of zirconium dioxide (ZrO). Meanwhile, a tribo-acoustic study indicated that the "squeaking" problem associated with ZrO could be suppressed by the biomimetic fluid. Together with a cytotoxicity assessment, the BSA nanoparticle-incorporated biomimetic fluid was confirmed as a potential reagent for use in the clinic to maintain an even longer service life of artificial joints.
人工关节润滑不足导致的过早失效是一个重大问题。受发动机润滑（其中使用各种添加剂来增强润滑油性能）的启发，在此进行了含有不同物质的仿生润滑液的台架试验。牛血清白蛋白（BSA）以分子和纳米颗粒两种形式用作功能添加剂。与BSA分子相比，分散在HA溶液中的BSA纳米颗粒在仿生润滑液中作为更有效的添加剂，可使由二氧化锆（ZrO）制成的陶瓷骨科材料的摩擦和磨损最小化。同时，摩擦声学研究表明，仿生液可以抑制与ZrO相关的“吱吱”问题。结合细胞毒性评估，含BSA纳米颗粒的仿生液被确认为一种有潜力用于临床的试剂，以维持人工关节更长的使用寿命。
