离子抗氧化剂功能化聚酰胺-胺型树枝状大分子和聚哌嗪型树枝状大分子的合成与活性

Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers.

作者信息

Bacha Katia, Estager Julien, Brassart-Pasco Sylvie, Chemotti Catherine, Fernandes Antony E, Mbakidi Jean-Pierre, Deleu Magali, Bouquillon Sandrine

机构信息

Molecular Chemistry Reims Institute UMR CNRS 7312, Reims Champagne-Ardenne University, Boîte n° 44, B.P. 1039, 51687 Reims, France.

Laboratory of Molecular Biophysics at Interfaces (LBMI), Gembloux Agro-Bio Tech-Liège University Passage des Déportés, 5030 Gembloux, Belgium.

出版信息

Polymers (Basel). 2022 Aug 27;14(17):3513. doi: 10.3390/polym14173513.

For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers were fully characterized and showed excellent antioxidant properties. Their cytotoxic properties have been also determined in the case of fibroblast dermal cells.