Departamento de Física Aplicada, Universidade de Vigo, 36310 Vigo, Spain; CINBIO, Universidade de Vigo, 36310 Vigo, Spain.
Roche-Chus Joint Unit, Translational Medical Oncology Group, Oncomet, Health Research Institute of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
J Colloid Interface Sci. 2023 Jan;629(Pt A):287-296. doi: 10.1016/j.jcis.2022.08.154. Epub 2022 Aug 28.
Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.
在生物相关介质中远程和磁力推进的拉长纳米结构作为治疗应用中的有效工具或载体引起了关注。然而，由于缺乏感兴趣的介质中的机械信息，考虑到生物物理或生物医学目的，相关的磁激励仍然具有挑战性。在这项研究中，我们详细描述了磁驱动链式纳米复合材料的动力学，其中可以根据所考虑的介质的粘度来调节它们的速度，给定磁场梯度。更简单的情况是蒸馏水、水/甘油混合物和由已知粘度的细胞提取物（模拟细胞的细胞质）制成的流体是研究 HeLa 细胞、鼠 NIH-3T3 成纤维细胞和斑马鱼幼虫内部更复杂介质的基础实验，提供所需的机械信息。实验结果表明，通过磁场梯度可以精确控制链式纳米结构的磁力推进性能，在需要药物和热传递、磁性分离或微流控技术的潜在变化情况下，提供涉及的动力学参数的良好估计。
