Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, China.
Front Immunol. 2022 Aug 22;13:757480. doi: 10.3389/fimmu.2022.757480. eCollection 2022.
CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular phagocytosis by macrophages, determines life span of individual erythrocytes, regulates activation of immune cells, and manipulates synaptic pruning during neuronal development. As such, CD47 has recently be regarded as one of novel innate checkpoint receptor targets for cancer immunotherapy. In this review, we will discuss increasing awareness about the diverse functions of CD47 and its role in immune system homeostasis. Then, we will discuss its potential therapeutic roles against cancer and outlines, the possible future research directions of CD47- based therapeutics against cancer.
CD47 广泛表达于细胞表面，在自我识别中发挥关键作用。通过与 SIRPα、TSP-1 和整合素相互作用，CD47 调节巨噬细胞的细胞吞噬作用，决定个体红细胞的寿命，调节免疫细胞的激活，并在神经元发育过程中操纵突触修剪。因此，CD47 最近被视为癌症免疫治疗的新型先天检查点受体靶标之一。在这篇综述中，我们将讨论对 CD47 多种功能及其在免疫系统稳态中的作用的认识不断提高。然后，我们将讨论其在抗癌治疗中的潜在作用，并概述针对癌症的基于 CD47 的治疗方法的可能未来研究方向。
