确定样本采集的最佳间隔时间：理论与列线图

Deciding the optimum interval between specimen collections: theory and nomograms.

作者信息

Fraser C G, Browning M C

出版信息

Clin Chem. 1987 Aug;33(8):1436-8.

Abstract

The time interval between collection of specimens from an individual patient is usually determined empirically. For analytes whose values decline according to first-order kinetics--for example, enzyme activities in serum after an acute myocardial infarction, tumor markers in serum after excision of the tumor, and drugs in serum after an overdose--the minimum time between collections (delta T) depends on the elimination half-life (t) and the analytical precision (CVA), according to the equation: delta T = (1/log2) X t X log (2.33 CVA/100 + 1). Nomograms showing this relationship graphically have been generated.

摘要

从个体患者采集标本的时间间隔通常凭经验确定。对于那些其值按一级动力学下降的分析物——例如，急性心肌梗死后血清中的酶活性、肿瘤切除后血清中的肿瘤标志物以及过量用药后血清中的药物——采集之间的最短时间间隔（ΔT）取决于消除半衰期（t）和分析精密度（CVA），根据以下公式：ΔT = (1/log2) × t × log (2.33 CVA/100 + 1)。已经生成了以图形方式显示这种关系的列线图。