胃旁路术后降低胃饥饿素水平并不影响其代谢获益。
Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.
机构信息
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, China.
Department of Pathology, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Aug 23;13:891379. doi: 10.3389/fendo.2022.891379. eCollection 2022.
OBJECTIVE
Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB).
DESIGN
Four-week-old WT and Ghrl-TSC1 mice were fed high fat diet for 12 weeks before surgery, and continued to be on the same diet for 3 weeks after surgery. Body weight, food intake, glycemic and lipid metabolism were analyzed before and after surgery.
RESULTS
Gastric and circulating ghrelin was significantly increased in mice with RYGB surgery. Hypoghrelinemia elicited by deletion of TSC1 to activate mTOR signaling in gastric X/A like cells demonstrated no effect on weight reduction, glycemic and lipid control induced by Roux-en-Y gastric bypass surgery.
CONCLUSION
Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.
目的
Roux-en-Y 胃旁路术是治疗代谢紊乱的有效干预措施。我们旨在阐明生长激素释放肽是否有助于减轻体重以及控制 Roux-en-Y 胃旁路术后（RYGB）的血糖和血脂。
设计
4 周龄 WT 和 Ghrl-TSC1 小鼠在手术前接受高脂肪饮食 12 周，手术后继续接受相同饮食 3 周。在手术前后分析体重、食物摄入量、血糖和血脂代谢。
结果
RYGB 手术后，胃和循环中的生长激素释放肽显著增加。通过删除 TSC1 激活胃 X/A 样细胞中的 mTOR 信号来引起的低生长激素释放肽血症，对 Roux-en-Y 胃旁路手术后减轻体重、控制血糖和血脂没有影响。
结论
较低的生长激素释放肽水平不会影响 Roux-en-Y 胃旁路手术带来的代谢益处。
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