Laudadio P, Caliceti U, Cerasoli P T, Rinaldi Ceroni A
Clin Otolaryngol Allied Sci. 1987 Jun;12(3):177-82. doi: 10.1111/j.1365-2273.1987.tb00184.x.
The correct management of mucoepidermoid tumours is still debatable because of their unpredictable biological course. The issue discussed is that of identifying biological characteristics of these tumours which may have predictive value. Sixteen patients with a mucoepidermoid tumour of the parotid gland, treated at the ENT Clinic of Bologna University over a 15-year period, were reviewed. The follow-up of each patient has been related to the surgical management, in order to evaluate whether superficial parotidectomy provides adequate treatment. No prognostic differences were noted between total and superficial parotidectomy when the latter was clinically appropriate. The histopathological specimens from these patients were reviewed in an attempt to correlate the histological grade of tumour with the course of the disease. Our data suggest that histological evaluation of malignancy alone is insufficient for accurate prognosis. We think that the clinical presentation (facial nerve palsy, pain, etc.) predicts the prognosis with greater accuracy.
由于黏液表皮样肿瘤的生物学进程不可预测,其正确的治疗方法仍存在争议。所讨论的问题是确定这些肿瘤可能具有预测价值的生物学特征。对在博洛尼亚大学耳鼻喉科诊所接受治疗的16例腮腺黏液表皮样肿瘤患者进行了为期15年的回顾性研究。为了评估浅叶腮腺切除术是否能提供充分的治疗,对每位患者的随访都与手术治疗相关。当浅叶腮腺切除术在临床上适用时,全腮腺切除术和浅叶腮腺切除术之间未发现预后差异。对这些患者的组织病理学标本进行了复查,试图将肿瘤的组织学分级与疾病进程相关联。我们的数据表明,仅靠恶性程度的组织学评估不足以准确判断预后。我们认为临床表现(面神经麻痹、疼痛等)对预后的预测更准确。