Department of Vascular Surgery, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania.
Department of Radiology, Biomedical Engineering Faculty, Grigore T. Popa University of Medicine and Pharmacy Iasi, Elena Doamna Obstetrics and Gynecology University Hospital, Iasi, Romania.
J Clin Lab Anal. 2022 Sep;36(9):e24645. doi: 10.1002/jcla.24645. Epub 2022 Aug 5.
Pregnancy is a prothrombotic condition which can be abnormally exaggerated in women with thrombophilia.
In a prospective study, patients who delivered at term, by cesarean section, between 1 October 2017 and 1 December 2021, who already had a diagnosis of thrombophilia before coming to our hospital, were included in the study group (n = 80). A similar number of nonthrombophilia patients (n = 80) without any history of thrombotic events, age- and para-matched with the study group, were included in the control group. The postpartum uterine ultrasonographic scale (PUUS) values, in the first 24-48 h, were correlated with the patients' data.
The P-LCR (platelet large cell ratio), was significantly higher in the treated thrombophilia group (p = 0.042). There was no correlation between PUUS and complete blood count values, coagulation factors, maternal characteristics, or fetal outcomes, except for postpartum neutrophils (p = 0.047) and postpartum platelet count (p = 0.046).
Postpartum uterine involution was not significantly different, after cesarean section, between treated thrombophilia patients and nonthrombophilia patients. Involution correlated only with postpartum neutrophils and postpartum platelet count.
妊娠是一种促血栓形成的状态,在患有血栓形成倾向的女性中可能异常加剧。
在一项前瞻性研究中,纳入了 2017 年 10 月 1 日至 2021 年 12 月 1 日期间足月剖宫产分娩且在来我院前已确诊血栓形成倾向的患者作为研究组(n=80)。选择年龄和产次匹配、无血栓形成事件史的非血栓形成倾向患者(n=80)作为对照组。在产后 24-48 小时内,通过产后子宫超声评分(PUUS)评估产后子宫收缩情况,并与患者的各项数据进行相关性分析。
治疗性血栓形成倾向组的血小板大细胞比(P-LCR)显著升高(p=0.042)。除了产后中性粒细胞(p=0.047)和产后血小板计数(p=0.046)外,PUUS 与全血细胞计数值、凝血因子、母体特征或胎儿结局均无相关性。
与非血栓形成倾向患者相比,治疗性血栓形成倾向患者的剖宫产术后子宫复旧无显著差异。子宫复旧仅与产后中性粒细胞和产后血小板计数相关。