Bishop D, Green A, Cantor S, Torresin W
Clin Exp Rheumatol. 1987 Apr-Jun;5(2):147-50.
The temporal relationship of rheumatoid arthritis activity and mood has rarely been studied and the findings have been unclear. This study focuses on this problem in a prospective, multiple assessment design. Depression, anxiety, and rheumatoid arthritis (R.A.) variables were assessed weekly during hospitalization and monthly for six months after discharge in a sample of 39 patients. Evidence was found for a relationship between depression and increased R.A. activity occurring in association with clinically relevant R.A. related events such as flare-ups leading to hospitalization, improvement resulting from hospitalization, and adjustment after discharge. No evidence was found for relationships between depression, anxiety, and less dramatic changes in R.A. variables occurring during regular weekly in-hospital and monthly post-hospital assessments. The results demonstrate the inadequacy of assessments done at one point in time and also suggest that somatic complaints such as reduced energy, disturbed sleep or poor appetite may be associated as much with depression as R.A. activity.
类风湿性关节炎活动与情绪之间的时间关系鲜有研究，且研究结果一直不明确。本研究以前瞻性、多次评估设计聚焦于此问题。在39名患者的样本中，住院期间每周以及出院后六个月每月对抑郁、焦虑和类风湿性关节炎（R.A.）变量进行评估。发现抑郁与类风湿性关节炎活动增加之间存在关联，这种关联与临床相关的类风湿性关节炎相关事件有关，如导致住院的病情突然加重、住院后病情改善以及出院后的调整。未发现抑郁、焦虑与每周定期住院评估和出院后每月评估期间类风湿性关节炎变量较轻微变化之间存在关联。结果表明，一次性评估是不充分的，还表明诸如精力下降、睡眠障碍或食欲不佳等躯体不适可能与抑郁以及类风湿性关节炎活动同样相关。
