Yang Wei, Yang Xiaoyan, Li Qing, Cao Pu, Tang Liyang, Xie Zhizhong, Lei Xiaoyong
Institute of Pharmacy and Pharmacology, School of Pharmacy, University of South China, Hengyang, China.
The Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, China.
Adv Clin Exp Med. 2023 Jan;32(1):97-106. doi: 10.17219/acem/152705.
Long non-coding RNAs are RNA molecules with a transcript length of more than 200 nucleotides and without protein-coding ability. They regulate gene expression by interacting with protein, RNA and DNA. Their function is closely related to their subcellular localization, with regulation of gene expression at the epigenetic and transcriptional levels occurring in the nucleus, and at the post-transcriptional and translational levels in the cytoplasm. Long stress-induced non-coding transcript 5 (LSINCT5), which is localized in the nucleus, is overexpressed in many types of cancers such as breast cancer, gastric cancer, ovarian cancer, thyroid cancer, and gastrointestinal cancer. Substantial evidence indicates that there is an obvious connection between cancers and LSINCT5, as it inhibits apoptosis and promotes proliferation, invasion and migration of cancer cells, as well as participates in the pathogenesis and progression of cancer by interacting with DNA, protein and RNA. These findings suggest that LSINCT5 could be a novel biomarker and an emerging therapeutic target in human cancers. In the present study, the structure and corresponding biological function of LSINCT5 were summarized in order to clarify its molecular mechanisms in the progression of various malignant tumors.
长链非编码RNA是一类转录本长度超过200个核苷酸且无蛋白质编码能力的RNA分子。它们通过与蛋白质、RNA和DNA相互作用来调节基因表达。其功能与其亚细胞定位密切相关，在细胞核中发生表观遗传和转录水平的基因表达调控，在细胞质中发生转录后和翻译水平的调控。定位于细胞核的长应激诱导非编码转录本5（LSINCT5）在多种癌症中过度表达，如乳腺癌、胃癌、卵巢癌、甲状腺癌和胃肠道癌。大量证据表明癌症与LSINCT5之间存在明显关联，因为它抑制细胞凋亡，促进癌细胞的增殖、侵袭和迁移，并通过与DNA、蛋白质和RNA相互作用参与癌症的发病机制和进展。这些发现表明LSINCT5可能是人类癌症中的一种新型生物标志物和新兴治疗靶点。在本研究中，总结了LSINCT5的结构和相应生物学功能，以阐明其在各种恶性肿瘤进展中的分子机制。
