虚拟记忆 CD8 T 细胞：起源与超越。
Virtual Memory CD8 T Cells: Origin and Beyond.
机构信息
Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
National Institutes of Health, Bethesda, Maryland, USA.
出版信息
J Interferon Cytokine Res. 2022 Dec;42(12):624-642. doi: 10.1089/jir.2022.0053. Epub 2022 Sep 9.
Abstract
The presence of CD8 T cells with a memory phenotype in nonimmunized mice has been noted for decades, but it was not until about 2 decades ago that they began to be studied in greater depth. Currently called virtual memory CD8 T cells, they consist of a heterogeneous group of cells with memory characteristics, without any previous contact with their specific antigens. These cells were identified in mice, but a few years ago, a cell type with characteristics equivalent to the murine ones was described in healthy humans. In this review, we address the different aspects of its biology mainly developed in murine models and what is currently known about its cellular equivalent in humans.
摘要
几十年来，人们一直注意到非免疫小鼠体内存在具有记忆表型的 CD8 T 细胞，但直到大约 20 年前，人们才开始更深入地研究它们。目前被称为虚拟记忆 CD8 T 细胞，它们由一群具有记忆特征的异质细胞组成，与它们的特定抗原没有任何先前接触。这些细胞在小鼠中被鉴定出来，但就在几年前，在健康人类中也描述了一种具有类似小鼠特征的细胞类型。在这篇综述中，我们主要讨论了在小鼠模型中发展起来的其生物学的不同方面，以及目前已知的人类中与其细胞等效物的相关内容。
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