钯促进的 DNA 上 Heck 反应。
Palladium-Promoted On-DNA Heck Reactions.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
出版信息
Methods Mol Biol. 2022;2541:55-61. doi: 10.1007/978-1-0716-2545-3_9.
PMID:36083544
Abstract
Optimal conditions of palladium-catalyzed on-DNA Heck reactions were developed between DNA-conjugated acryl amide/styrene/aryl iodide and broad substrate scopes (aromatic borates/halides/styrene), which can introduce the diversity of building blocks to DNA-encoded libraries.
摘要
发展了钯催化的 DNA 上 Heck 反应的最佳条件，该反应发生在 DNA 偶联丙烯酰胺/苯乙烯/芳基碘化物与广泛底物范围（芳基硼酸酯/卤化物/苯乙烯）之间，这可以将不同的构建块引入 DNA 编码文库中。
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