DNA 偶联亚胺与均苯四甲酸二酐缩合用于 DNA 上异喹啉酮的合成。
Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones On-DNA.
机构信息
Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GlaxoSmithKline, Cambridge, MA, USA.
出版信息
Methods Mol Biol. 2022;2541:75-79. doi: 10.1007/978-1-0716-2545-3_12.
PMID:36083547
Abstract
Condensation of imines with anhydrides has been proven to be a valuable method for the synthesis of tetrahydroisoquinolines. Herein, we describe the application of this chemistry with DNA-conjugated imines. It is proven to be an efficient way to deliver isoquinolone chemotypes for DNA-encoded library.
摘要
亚胺与酸酐的缩合已被证明是合成四氢异喹啉的一种很有价值的方法。在此，我们描述了这种化学方法在 DNA 偶联亚胺中的应用。事实证明，这是一种为 DNA 编码文库提供异喹啉类化合物的有效方法。
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