高通量结合物确认的亲和选择质谱法。
High-Throughput Binder Confirmation Using Affinity Selection Mass Spectrometry.
机构信息
Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GlaxoSmithKline, Cambridge, MA, USA.
出版信息
Methods Mol Biol. 2022;2541:215-223. doi: 10.1007/978-1-0716-2545-3_25.
PMID:36083560
Abstract
Affinity selection mass spectrometry (AS-MS) was recently applied to a new high-throughput binder confirmation (HTBC) platform. The HTBC-AS-MS platform can assess target engagement for hundreds of chemical series per target and is used at GSK to prioritize synthesis decisions for follow-up organic synthesis of DNA-encoded library technology (ELT) hits.
摘要
亲和选择质谱法 (AS-MS) 最近被应用于一种新的高通量结合物确认 (HTBC) 平台。HTBC-AS-MS 平台可针对每个靶标评估数百个化学系列的靶标结合，并且在 GSK 中用于对后续 DNA 编码文库技术 (ELT) 命中的有机合成决策进行优先级排序。
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