花提取物的类黄酮成分、抗氧化、抗胆碱酯酶和细胞毒性活性
Flavonoids composition, antioxidant, anticholinesterase, and cytotoxic activities of flowers extract of Afr. Fern.
机构信息
Department of Organic and Inorganic Chemistry/Department of Analytical Chemistry and Physico-Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
出版信息
Nat Prod Res. 2023 Jun;37(11):1892-1896. doi: 10.1080/14786419.2022.2121922. Epub 2022 Sep 9.
The genus has a wide diversity of species, with an interesting chemical composition of secondary metabolites and applications as medicine. The folk medicine, mainly in developing countries, uses species of to treat seizures, epilepsy and constipation. Though the recognized bioactivity, some Brazilian native species of remain unexplored, such as , a native species of Caatinga. This is the first report about the bioactivity of the flowers of Afr. Fern., a native species of northeast Brazil. In this communication, flavonoids and catechins are identified in flowers and the chemical composition is linked with its antioxidant, anticholinesterase, and cytotoxic activities. By UPLC-QTOF, some compounds that belong to the class of flavonoids were identified. They are: catechin, epigallocatechin, guibourtinidol-(4α-8)-catechin, and cassiaflavan-(Cat)-epicatechin. The cytotoxic activity is more noticeable for the HL60 (leukemia) cell line with a cell growth inhibition (GI%) of 81.65 ± 5.65.
该属具有广泛的物种多样性，其次生代谢产物具有有趣的化学成分，并在医学领域得到应用。民间医学，主要在发展中国家，使用 属的物种来治疗癫痫发作、癫痫和便秘。尽管具有公认的生物活性，但一些巴西本土的 属物种仍未被探索，例如来自卡廷加地区的本地物种 。这是关于巴西东北部本土物种 Afr. Fern. 的花朵的生物活性的第一个报告。在本通讯中，鉴定了 Afr. Fern. 花中的类黄酮和儿茶素，其化学成分与抗氧化、抗胆碱酯酶和细胞毒性活性相关联。通过 UPLC-QTOF，鉴定了属于类黄酮类的一些化合物。它们是：儿茶素、表没食子儿茶素、guibourtinidol-(4α-8)-儿茶素和肉桂酰化（Cat）-表儿茶素。细胞毒性活性在 HL60（白血病）细胞系中更为明显，细胞生长抑制（GI%）为 81.65±5.65。
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